منابع مشابه
Wnt signaling transcription factors TCF-1 and LEF-1 are upregulated in malignant astrocytic brain tumors.
Since the discovery of the TCF/LEF family of transcription factors, their functions have been under intensive investigation in the area of cancer biology. The work presented in this paper focused on the changes in TCF-1 and LEF-1 expression levels in a set of astrocytic brain tumors. Protein expression was detected using immunohistochemistry and then evaluated by Ellipse software (ViDiTo, Slova...
متن کاملTypes of glioma brain tumors and genetic alterations in signaling pathways in them
Types of glioma brain tumors and genetic alterations in signaling pathways in them Background & Objective: Glioma is a common type of primary brain tumor originating in the glial cells that surrounds and supports neurons in the brain. These tumors arise from three different types of cells that are normally found in the brain: astrocytes, oligodendrocytes, and ependymal cells, accordingly types ...
متن کاملThe Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy
Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...
متن کاملMetabolic profile of lipid extracts obtained by astrocytic brain tumors
Introduction Astrocytic brain tumors – Gliomas in particular – are the most common brain tumors in adults. These malignant neoplasms are characterized by heterogeneous tissue with no distinct differentiation to healthy tissue because of their infiltrative growth. Therefore, the ratio of tumor cells versus healthy tissue in the tumor margin needs to be determined very precisely when the decision...
متن کاملIdentification of lipids in tissue extracts of astrocytic brain tumors
Prerequisite for accurate resections of human brain tumors is the differentiation between tissue of tumor core and tumor margin. All tumor tissue needs to be removed to avoid tumor relaps and to enhance prognosis, but healthy tissue should not be resected coevally in order to maintain normal brain functions. Therefore, the amount of tumor cells and healthy cells in the margin of the tumor is cr...
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ژورنال
عنوان ژورنال: CNS Oncology
سال: 2015
ISSN: 2045-0907,2045-0915
DOI: 10.2217/cns.15.24